Cardiovascular outcomes of semaglutide and tirzepatide for patients with type 2 diabetes in clinical practice
Nature Medicine, Published online: 09 November 2025; doi:10.1038/s41591-025-04102-x
As presented at AHA Scientific Sessions 2025, in a trial emulation analysis including benchmarking to data from randomized clinical trials, treatment with semaglutide and tirzepatide showed similar levels of benefit on cardiovascular outcomes in individuals at elevated cardiovascular risk with obesity and diabetes.
Cardiovascular outcomes of semaglutide and tirzepatide for patients with type 2 diabetes in clinical practice
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