Physical activity linked to slower tau protein accumulation and cognitive decline
Nature Medicine, Published online: 11 November 2025; doi:10.1038/s41591-025-04081-z
In older adults without cognitive impairment with higher levels of brain amyloid-β, physical inactivity was associated with accelerated accumulation of tau pathology and faster cognitive and functional decline. These findings suggest that even modest increases in daily physical activity might be linked to slower progression of preclinical Alzheimer’s disease.
Physical activity linked to slower tau protein accumulation and cognitive decline
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