Month: January 2023

Nature Medicine, Published online: 26 January 2023; doi:10.1038/s41591-022-02163-w

Genomic analyses in large cohorts of patients with cancer identify a new measure of tumor mutational burden, based on genomic regions that are unlikely to undergo loss, that is associated with therapeutic response to immunotherapy.
  • January 26, 2023
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Nature Medicine, Published online: 26 January 2023; doi:10.1038/s41591-022-02181-8

Patients with BRAFV600E-mutated colorectal cancer have encouraging overall response rates to inhibition of PD-1, BRAF and MEK, with translational analyses suggesting that induction of tumor-intrinsic programs and immune programs contributes to improved outcomes via MAPK inhibition.
  • January 26, 2023
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Nature Medicine, Published online: 26 January 2023; doi:10.1038/s41591-022-02180-9

A smartphone-based system, designed to induce a steady gaze in children using cartoon-like video stimuli, can identify visually impaired children across a wide range of ophthalmic disorders, based on analysis of gazing behaviors and facial features.
  • January 26, 2023
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Xavier held on for a victory over Connecticut in a crucial Big East battle Wednesday on FS1. Here are the top plays!
  • January 25, 2023
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Rihanna won't be the only one taking the stage at the Super Bowl LVII. Sheryl Lee Ralph and Babyface will also be serenading us.
  • January 25, 2023
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There’s nothing more inside sports than talking shop about general managers and team presidents. Obviously, their job is vital to the success of the organization. It’s just, no one really needs to know more than that. Golden State Warriors GM Bob Myers has been leaking his contract negotiations to the press since…

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  • January 25, 2023
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As Signing Day approaches, Nease High’s disgraced quarterback Marcus Stokes has a second chance at fulfilling his college football aspirations. After a senior season in which Stokes gained 2,672 yards, rushed for 496 yards, and scored 28 touchdowns, the four-star passer (or 3-star, depending on where you look)…

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  • January 25, 2023
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Patrick Mahomes practiced Wednesday and reaffirmed that he'll be "ready to go" for the AFC Championship Game despite a high-ankle sprain.
  • January 25, 2023
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Lyonne plays a cocktail waitress with an odd psychic power: She can sense when people aren't telling the truth, which makes her a great (accidental) detective in this delightful new Peacock series.
  • January 25, 2023
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Odesa in Ukraine has been added to the cultural sites that UNESCO is highlighting. Also being included are ancient sites in Lebanon and Yemen.
  • January 25, 2023
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