wellness

Nature Medicine, Published online: 12 June 2026; doi:10.1038/s41591-026-04431-5

In an independent evaluation, frontier large language models outperformed specialized clinical artificial intelligence tools on medical knowledge, clinician alignment and real-world clinical queries.

Nature Medicine, Published online: 12 June 2026; doi:10.1038/s41591-026-04465-9

Pramipexole, in patients with major depressive disorder, dysthymia or bipolar depression, reduced Snaith−Hamilton Pleasure Scale scores significantly compared to placebo.

Nature Medicine, Published online: 12 June 2026; doi:10.1038/s41591-026-04421-7

The Hong Kong Genome Project established a genome sequencing database that provides improved diagnoses for patients and more efficient, population-tailored carrier status screening. Actionable pharmacogenomic variants were identified in almost all participants, informing drug prescriptions. This work establishes a genomic resource and a transferable model for equitable precision medicine in underrepresented populations worldwide.

Nature Medicine, Published online: 11 June 2026; doi:10.1038/s41591-026-04510-7

Clinical Profile and Genomic Characterization of the 2026 Bundibugyo Virus Index Case in Uganda

Nature Medicine, Published online: 11 June 2026; doi:10.1038/s41591-026-04409-3

We analyzed brains from octogenarians and cognitively resilient centenarians to understand why some individuals with substantial Alzheimer’s disease pathology develop dementia whereas others remain cognitively intact. Spatial transcriptomics revealed gene expression changes in discrete tissue domains surrounding amyloid plaques and tau pathology that distinguish early, clinically silent, disease from later stages associated with cognitive decline.

Nature Medicine, Published online: 10 June 2026; doi:10.1038/s41591-026-04436-0

Phase 1 results reveal that BBM-P002, a dual-target gene therapy co-delivering TH and DDC, is safe and well tolerated in Parkinson’s disease, with 12-month motor improvements signaling therapeutic potential.

Nature Medicine, Published online: 10 June 2026; doi:10.1038/s41591-026-04444-0

Announced in this Comment and in collaboration with Nature Medicine is the convening of the Brain Health for Economic Resilience Commission, a global, transdisciplinary effort to define, measure and operationalize brain health and cognitive capacity as foundational drivers of economic resilience.

According to the Insurance Institute for Highway Safety, more teen car crash deaths happen in June than any other month. Saturday and Sunday tend to be the most dangerous days for driving teens.

Nature Medicine, Published online: 09 June 2026; doi:10.1038/s41591-026-04482-8

Bundibugyo Ebola without vaccines or therapeutics: why public health fundamentals matter more than border closures

Nature Medicine, Published online: 09 June 2026; doi:10.1038/s41591-026-04429-z

An interim report of a first-in-human phase 1 trial found an adjuvanted, combination inactivated rabies-vectored, Lassa fever vaccine (LASSARAB + 3D-6-acyl PHAD-SE) to be safe and induced immunogenicity to both Lassa and rabies viruses in healthy participants.