health

Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04538-9

In phase 1b/2 trial, the treatment of patients with metastatic KRASG12D-mutant pancreatic cancer, the intravenously delivered KRAS-G12D inhibitor HRS-4642 plus nab-paclitaxel and gemcitabine led to encouraging clinical response rates that support investigation in larger trials.

Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04484-6

Once confined to post-market surveillance, real-world evidence is now being used to emulate trials, guide approvals and even run studies in real time, forcing a rethink of what constitutes a clinical trial.

Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04490-8

The 2024 revision of the McDonald diagnostic criteria is an important step toward earlier and more inclusive diagnosis of multiple sclerosis. Realizing its full potential will require continued refinement of biomarkers, disease stratification and clinical trial approaches.

Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04512-5

The immune-privileged environment of the inner ear permits sequential bilateral gene therapy for one form of congenital deafness, which adds to growing evidence of the feasibility, safety and efficacy of this innovative curative treatment.

Nature Medicine, Published online: 08 July 2026; doi:10.1038/s41591-026-04531-2

Benchmark estimates from 2017–2021 provide an updated assessment of progress toward the WHO Global Breast Cancer Initiative survival targets across all 194 Member States.

Nature Medicine, Published online: 08 July 2026; doi:10.1038/s41591-026-04554-9

As a new generation of cancer drugs continues to extend the lives of people with cancer, strategies for recording and managing their toxicity and long-term effects will need innovation too.

Forager Project has expanded its dairy-free creamer portfolio with Golden Salted Caramel, Banana Bread and Mexican Chocolate. The launch reflects growing consumer demand for more indulgent, comforting flavors in the plant-based creamer category while maintaining a clean-label ingredient list.

Nature Medicine, Published online: 07 July 2026; doi:10.1038/s41591-026-04511-6

Multiomics profiling of extracorporeal cross-circulation with gene-edited pig liver xenografts in four human decedents provides comprehensive information on immune, coagulation and metabolic parameters that will help in the clinical development of this strategy for delivering hepatic support to patients with liver failure.

Nature Medicine, Published online: 07 July 2026; doi:10.1038/s41591-026-04411-9

Whole genomes of Oropouche virus were sequenced in Cuba from people infected during the 2024 outbreak, and phylogenetic analyses suggest that this Cuban subclade was introduced through a single introduction from Brazil in early 2024.

Nature Medicine, Published online: 07 July 2026; doi:10.1038/s41591-026-04472-w

A first-in-human, partially randomized and placebo-controlled phase I trial examined the safety, tolerability, pharmacokinetics and antiviral activity of the bispecific 10E8.4/iMab broadly neutralizing monoclonal antibody in people living with or without HIV, and found it was safe and well tolerated at different dose levels and routes of administration.