Health

Nature Medicine, Published online: 04 July 2025; doi:10.1038/s41591-025-03789-2

When tested in a multiethnic cohort of ~2.5 million US veterans, the PREVENT equations, recently developed by the American Heart Association for sex-specific and race-free prediction of cardiovascular disease risk, were shown to accurately estimate this risk with some variability across race and ethnicity groups and to outperform the previously used pooled cohort equation risk score.

Nature Medicine, Published online: 03 July 2025; doi:10.1038/d41591-025-00043-7

Instead of making one-off treatments, industrialized gene therapy might be able to treat multiple diseases.

Nature Medicine, Published online: 03 July 2025; doi:10.1038/s41591-025-03815-3

Trials for LLM-supported clinical decisions in African primary healthcare

Nature Medicine, Published online: 03 July 2025; doi:10.1038/s41591-025-03806-4

Co-designing a public health data analytics platform

Nature Medicine, Published online: 02 July 2025; doi:10.1038/s41591-025-03773-w

Preliminary results from an investigator-initiated clinical trial showed that an AAV-OTOF gene therapy was safe and led to hearing improvements in ten patients with congenital deafness with 6–12 months of follow-up, including in a teenager and a young adult, expanding the age range from previous trials.

Nature Medicine, Published online: 02 July 2025; doi:10.1038/s41591-025-03796-3

Campaigners want ultra-processed foods to be better defined and regulated. But does the evidence support strong policy changes?

Nature Medicine, Published online: 02 July 2025; doi:10.1038/s41591-025-03755-y

An explosion of digital tools and AI is catalyzing innovations in the mission to scale up mental health support worldwide. These paradigms currently rely on a ‘human in the loop’ — but who is the human in question, and does it matter?

Nature Medicine, Published online: 02 July 2025; doi:10.1038/s41591-025-03816-2

Rethinking TREM2 as a target for Alzheimer’s disease after the INVOKE-2 trial failure

Nature Medicine, Published online: 01 July 2025; doi:10.1038/s41591-025-03805-5

The global rollback of transgender care, science and rights

Nature Medicine, Published online: 01 July 2025; doi:10.1038/s41591-025-03832-2

A randomized phase 2a clinical trial of an AI-discovered drug and target combination for idiopathic pulmonary fibrosis shows safety and signs of efficacy, marking a concrete step forward in bringing AI-enabled drug discovery into the clinic.