Patient stratification for determining optimal second-line and third-line therapy for type 2 diabetes: the TriMaster study

Patient stratification for determining optimal second-line and third-line therapy for type 2 diabetes: the TriMaster study

Nature Medicine, Published online: 07 December 2022; doi:10.1038/s41591-022-02120-7

Using a randomized three-way crossover design and stratification approaches based on obesity and renal function in people with type 2 diabetes, the TriMaster study demonstrated that patients with obesity were more likely to have greater glycemic control with pioglitazone (a thiazolidinedione) than with sitagliptin (a DPP4 inhibitor) and that patients with eGFR 60–90 ml/min/1.73 m2 were more likely to achieve lower HbA1c levels on sitagliptin than on canagliflozin (an SGLT2 inhibitor).

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Patient stratification for determining optimal second-line and third-line therapy for type 2 diabetes: the TriMaster study

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