Low-dose spironolactone and cardiovascular outcomes in moderate stage chronic kidney disease: a randomized controlled trial
Nature Medicine, Published online: 30 September 2024; doi:10.1038/s41591-024-03263-5
A randomized controlled trial involving patients with stage 3b chronic kidney disease from primary care reported that in contrast to reported cardiorenal protective effects of nonsteroidal mineralocorticoid receptor antagonists (MRA), the steroidal MRA spironolactone did not reduce mortality or cardiovascular disease hospitalization compared to usual care.
Low-dose spironolactone and cardiovascular outcomes in moderate stage chronic kidney disease: a randomized controlled trial
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