HIV-1 remission following stem cell transplant without CCR5Δ32 mutation

HIV-1 remission following stem cell transplant without CCR5Δ32 mutation

Nature Medicine, Published online: 06 November 2024; doi:10.1038/s41591-024-03365-0

We report the first case of a person achieving sustained HIV-1 remission after transplantation with allogeneic hematopoietic stem cells that express wild-type CCR5 and thus are permissive to HIV-1 infection. The 53-year-old man received the transplant in 2018 to treat a rare myeloid sarcoma and has not experienced viral rebound since discontinuing antiretroviral therapy in November 2021.

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HIV-1 remission following stem cell transplant without CCR5Δ32 mutation

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