Inflammation and disrupted hematopoiesis drive clonal dominance in a mouse model of VEXAS syndrome
Nature Medicine, Published online: 08 April 2025; doi:10.1038/s41591-025-03670-2
We show that hematopoiesis in a mouse model of VEXAS syndrome is subverted by inflammation-resilient, senescent-like mutant HSPCs, which have dysfunctional differentiation and undermine hematopoiesis through their proinflammatory progeny. This disease mechanism explains clonal dominance and bone marrow failure (BMF) in patients with VEXAS syndrome and could have translational implications.
Inflammation and disrupted hematopoiesis drive clonal dominance in a mouse model of VEXAS syndrome
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