Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial
Nature Medicine, Published online: 10 July 2025; doi:10.1038/s41591-025-03830-4
In a phase 1 trial, treatment of individuals with mixed hyperlipidemia with a monoclonal antibody targeting the angiopoietin-like protein 3/8 complex resulted in dose-dependent reductions in the levels of triglycerides and low-density lipoprotein cholesterol, while increasing the levels of high-density lipoprotein.
Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial
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