Tirzepatide drives weight loss in people with obesity due to MC4R deficiency
Nature Medicine, Published online: 05 September 2025; doi:10.1038/s41591-025-03915-0
We studied people with obesity involved in the SURMOUNT-1 trial of the dual GLP-1 and GIP receptor agonist, tirzepatide. People with pathogenic variants of the gene encoding the melanocortin 4 receptor (MC4R) lost a similar amount of weight to people with an intact gene, demonstrating that tirzepatide is effective in MC4R deficiency.
Tirzepatide drives weight loss in people with obesity due to MC4R deficiency
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