Diagnosing ALS: a surprisingly arduous hike lasting 150 years

Diagnosing ALS: a surprisingly arduous hike lasting 150 years

Nature Medicine, Published online: 22 September 2025; doi:10.1038/s41591-025-03989-w

We introduce a diagnostic biomarker for amyotrophic lateral sclerosis that distinguishes it from similar conditions by examining a combination of plasma proteins. This innovation also offers insights into the underlying mechanisms of the disease, highlighting a compensatory process in skeletal muscle and bioenergetics that seems to start much earlier than previously thought.

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Diagnosing ALS: a surprisingly arduous hike lasting 150 years

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