Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk
Nature Medicine, Published online: 16 October 2025; doi:10.1038/s41591-025-03976-1
The authors explore the impact of MC4R deficiency on lipid metabolism in humans, based on two large cohorts. Findings indicate that individuals with obesity due to MC4R deficiency have lower cholesterol and triglyceride levels, as well as reduced cardiovascular risk.
Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk
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