Mechanistic insights make cancer cachexia a targetable syndrome
Nature Medicine, Published online: 02 January 2026; doi:10.1038/s41591-025-04109-4
Two studies establish a mechanism, biomarker and therapeutic strategy for cancer cachexia, all centered around the HIF-2 pathway. The findings reframe this intractable metabolic syndrome as a pharmacologically treatable condition.
Mechanistic insights make cancer cachexia a targetable syndrome
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