A cell atlas of human endometrium reveals key molecular and cellular alterations in PCOS
Nature Medicine, Published online: 11 April 2025; doi:10.1038/s41591-025-03672-0
A human cellular and molecular atlas of the proliferative endometrium in polycystic ovary syndrome (PCOS) was generated via single-nucleus RNA sequencing and spatial transcriptomics. This study reveals PCOS-specific alterations in cellular composition and gene expression, and identifies potential therapeutic targets. These findings could advance treatments for PCOS-related endometrial dysfunction and associated health challenges.
A cell atlas of human endometrium reveals key molecular and cellular alterations in PCOS
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