A low-toxicity linezolid analog has potential for use in all patients with tuberculosis
Nature Medicine, Published online: 15 January 2026; doi:10.1038/s41591-025-04188-3
Systematic examination of oxazolidinone analogs for activity against Mycobacterium tuberculosis and limited inhibition of the synthesis of mitochondrial proteins enabled the identification of several compounds with safety suitable for once-daily dosing. The lead molecule is effective in mouse models of disease and safe in four-month toxicity studies.
A low-toxicity linezolid analog has potential for use in all patients with tuberculosis
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