A meta-analysis of albuminuria as a surrogate endpoint for kidney failure
Nature Medicine, Published online: 06 November 2025; doi:10.1038/s41591-025-04057-z
In a meta-analysis of 48 randomized trials of chronic kidney disease progression, reduction in the 6-month urinary albumin:creatinine ratio was associated with lower hazard ratios of established kidney disease endpoints, supporting the use of albuminuria change as a surrogate endpoint in clinical trials for chronic kidney disease.
A meta-analysis of albuminuria as a surrogate endpoint for kidney failure
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