A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
Nature Medicine, Published online: 30 October 2024; doi:10.1038/s41591-024-03215-z
Single-nucleus and single-cell RNA sequencing plus spatial profiling with four methods of core biopsies from 60 patients with metastatic breast cancer reveal patient-specific gene expression programs of breast cancer metastases that are maintained across time, site of metastasis and spatial profiling method, with spatial phenotypes correlating with microenvironmental features.
A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
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