APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases

APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases

Nature Medicine, Published online: 15 July 2025; doi:10.1038/s41591-025-03835-z

Over 11,000 plasma and cerebrospinal fluid proteomic samples reveal that the APOE ε4 genetic variant is associated with a systemic pro-inflammatory signature in a variety of neurodegenerative diseases.

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APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases

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