Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial
Nature Medicine, Published online: 06 January 2025; doi:10.1038/s41591-024-03334-7
In this phase 1 trial, patients with locally advanced or metastatic solid tumors were treated with the individualized mRNA neoantigen-specific immunotherapy (iNeST) autogene cevumeran alone or in combination with the anti-PD-L1 agent atezolizumab, showing long-lasting neoantigen-specific immune responses and preliminary clinical activity, supporting further development of this therapeutic approach.
Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial
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