Broad versus limited gene panels to guide treatment in patients with advanced solid tumors: a randomized controlled trial

Broad versus limited gene panels to guide treatment in patients with advanced solid tumors: a randomized controlled trial

Nature Medicine, Published online: 07 April 2025; doi:10.1038/s41591-025-03613-x

Results from the randomized ProfiLER-02 trial, which compared two gene panels in guiding molecular-based treatment in patients with solid tumors, show that a broader gene panel led to more molecular-based recommended therapies compared to a more limited gene panel.

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Broad versus limited gene panels to guide treatment in patients with advanced solid tumors: a randomized controlled trial

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