Health

Nature Medicine, Published online: 13 February 2026; doi:10.1038/s41591-026-04218-8

This Comment discusses how best to navigate an increasingly complex and dynamic research and innovation landscape in health.

Nature Medicine, Published online: 13 February 2026; doi:10.1038/s41591-026-04232-w

Inclusion by Design is a governance blueprint for auditable representation across trials and data infrastructures

Nature Medicine, Published online: 13 February 2026; doi:10.1038/d41591-026-00009-3

Climate change could result in an additional 123 million malaria cases in Africa by 2050, driven mostly by extreme weather events — which calls for climate-resilient malaria control strategies.

Many things in this world cannot be changed, but type 2 diabetes can be reversed. Research from the 2024–2025 American Diabetes Association (ADA) shows that dietary changes can improve how people manage diabetes. In some cases, these changes can even reverse the condition. You can regain your health and energy, and feel more in control, …

Continue reading "Type 2 diabetes reversal: 5 foods that could change your life"

Nature Medicine, Published online: 12 February 2026; doi:10.1038/s41591-026-04207-x

The authors developed a microfluidic device, FIND-Chip, designed to automate and enhance oocyte recovery from follicular fluid, a process traditionally done manually. When used in clinical settings, the device recovered additional oocytes missed during manual screening, substantially increasing the number of viable oocytes available for in vitro fertilization.

Nature Medicine, Published online: 12 February 2026; doi:10.1038/s41591-026-04208-w

A cluster-randomized trial in rural Lesotho showed that uncontrolled hypertension diagnosis and management delivered by minimally trained lay persons in the community using a mobile decision support tool was superior to facility referral for improving clinical outcomes.

Nature Medicine, Published online: 12 February 2026; doi:10.1038/s41591-025-04139-y

A follow-up analysis of a clinical trial that evaluated anti-PD-1 therapy in patients with cancer who are living with HIV provides mechanistic insights into transcriptomic, cellular and cytokine changes related to immune checkpoint inhibitor treatment and identifies a signature associated with clinical response.

Nature Medicine, Published online: 12 February 2026; doi:10.1038/s41591-025-04152-1

PD-1 blockade reprograms both innate and adaptive immunity in people living with HIV and cancer, inducing interferon-driven antiviral responses that reduce the HIV reservoir. A pre-existing type I interferon signature predicts reservoir decline, whereas high TGFβ signaling opposes it, defining immune states that influence the outcome of PD-1 therapy.

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Nature Medicine, Published online: 11 February 2026; doi:10.1038/s41591-025-04178-5

PRIMARY-AI: outcomes-based standards to safeguard primary care in the AI era