Health

Nature Medicine, Published online: 05 September 2025; doi:10.1038/s41591-025-03945-8

A report from the first 2,000 newborns enrolled in the Early Check program, which offered genome screening covering 198 genes associated with early-onset diseases, shows the feasibility and potential clinical utility of the approach, leading to 28 true positive results.

Nature Medicine, Published online: 05 September 2025; doi:10.1038/s41591-025-03938-7

A digital twin, or virtual organ, can help clinicians and patients make better decisions, and can even help in the design of more-efficient clinical trials.

Nature Medicine, Published online: 05 September 2025; doi:10.1038/s41591-025-03915-0

We studied people with obesity involved in the SURMOUNT-1 trial of the dual GLP-1 and GIP receptor agonist, tirzepatide. People with pathogenic variants of the gene encoding the melanocortin 4 receptor (MC4R) lost a similar amount of weight to people with an intact gene, demonstrating that tirzepatide is effective in MC4R deficiency.

Nature Medicine, Published online: 05 September 2025; doi:10.1038/s41591-025-03940-z

Imaging data support the clinical effects of RNA interference agent vutrisiran in patients with transthyretin amyloidosis with cardiomyopathy — and point to a potential new role for echocardiographic parameters in monitoring individual treatment responses.

Nature Medicine, Published online: 04 September 2025; doi:10.1038/s41591-025-03935-w

In the secondary endpoint analysis of the phase 3 SONIA trial, circulating tumor DNA (ctDNA) analysis showed that a pretreatment aneuploidy-based high ctDNA level in patients with advanced breast cancer was associated with benefit from first-line treatment with CDK4/6 inhibitors.

Nature Medicine, Published online: 04 September 2025; doi:10.1038/s41591-025-03885-3

In this single-arm phase 2 trial in patients with HR+HER2− advanced breast cancer, treatment with the HER3-targeting antibody–drug conjugate paritumab deruxtecan led to encouraging objective response rates, and comprehensive exploratory analyses indicate potential biomarkers of response.

Nature Medicine, Published online: 04 September 2025; doi:10.1038/s41591-025-03921-2

Luis Diaz describes how a molecular blood assay revealed the tiniest traces of DNA from a tumor, changing how we monitor cancer.

Nature Medicine, Published online: 04 September 2025; doi:10.1038/s41591-025-03908-z

Improving the evidence base for COVID-19 vaccines

Based on a streamlined survey, this year’s lists of top pediatric centers will be published October 7.

The term “sandwich generation” refers to middle-aged parents who care for both their young children and their aging parents. Now, with more adult children returning home due to the high costs of housing, childcare, and other economic factors, social scientists have coined the term “club sandwich generation” to reflect the additional responsibility. It’s a growing phenomenon: Multigenerational families made up only 4.7 percent of U.S. households in 2010, but by 2020 that number had nearly doubled. And the rate could be even higher—according to a study by Pew Research, about 60 to 70 million people in the United States lived with multiple generations in 2021.