Health

Nature Medicine, Published online: 15 April 2025; doi:10.1038/s41591-025-03635-5

CONSORT 2025 provides updated guidance to authors, reviewers and editors, when writing and evaluating manuscripts of randomized trials to ensure that trial reports are clear and transparent

Nature Medicine, Published online: 14 April 2025; doi:10.1038/d41591-025-00025-9

The first pig liver to be transplanted into a human (in this case, a brain-dead recipient) showed sustained function without rejection — marking another step toward xenotransplantation as a viable approach to addressing the organ-shortage crisis.

Nature Medicine, Published online: 11 April 2025; doi:10.1038/s41591-025-03649-z

The World Health Organization’s inaugural Investment Round aims to instill stability in the face of global health headwinds and a US exit.

Nature Medicine, Published online: 11 April 2025; doi:10.1038/s41591-025-03689-5

Author Correction: Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults

Nature Medicine, Published online: 11 April 2025; doi:10.1038/s41591-025-03672-0

A human cellular and molecular atlas of the proliferative endometrium in polycystic ovary syndrome (PCOS) was generated via single-nucleus RNA sequencing and spatial transcriptomics. This study reveals PCOS-specific alterations in cellular composition and gene expression, and identifies potential therapeutic targets. These findings could advance treatments for PCOS-related endometrial dysfunction and associated health challenges.

Nature Medicine, Published online: 11 April 2025; doi:10.1038/s41591-025-03608-8

The ONCOBIOME network has generated new tools to measure dysbiosis and completed numerous trials aimed at modifying the microbiota to enhance cancer treatment; this Review summarizes the key advances and the progress toward translating them into clinical practice.

Nature Medicine, Published online: 10 April 2025; doi:10.1038/d41591-025-00024-w

The success of new non-opioid drugs and other treatments for pain offer some relief for sufferers.

Nature Medicine, Published online: 10 April 2025; doi:10.1038/s41591-025-03638-2

In a phase 1/2 trial in patients with advanced non-small-cell lung cancer (NSCLC), followed by a phase 2 trial in an EGFR-mutant selected population, treatment with the TROP2-targeting antibody–drug conjugate sacituzumab tirumotecan led to encouraging clinical response rates, especially in patients with EGFR-mutant NSCLC, which was supported by mechanistic data.

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Nature Medicine, Published online: 09 April 2025; doi:10.1038/s41591-025-03644-4

Clinical and genomic mapping of a large sample of invasive nontyphoidal Salmonella infections sheds light on the global spread of this pathogen and its acquisition of antimicrobial resistance features and indicates future potential for human-to-human transmission.