- November 28, 2025
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Nature Medicine, Published online: 28 November 2025; doi:10.1038/s41591-025-04054-2
In vivo experiments and clinical cohort analyses show that hypoxia-inducible factor 2 (HIF2)-induced parathyroid hormone-related protein (PTHrP) expression contributes to cachexia in the context of renal cell carcinoma (RCC). The pathway can be targeted by HIF2 inhibitors, including belzutifan, which may reduce cachexia in patients with RCC.- November 28, 2025
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Nature Medicine, Published online: 27 November 2025; doi:10.1038/s41591-025-04061-3
Assessing the value of genomics is key to informing evidence-based policies; this Review outlines how current approaches to health technology assessment, implementation and data management can be adapted to suit the rapidly evolving technology and evidence base.- November 27, 2025
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Nature Medicine, Published online: 27 November 2025; doi:10.1038/s41591-025-04118-3
Author Correction: Spatial multiomic landscape of the human placenta at molecular resolution- November 27, 2025
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Nature Medicine, Published online: 26 November 2025; doi:10.1038/d41591-025-00068-y
A phase 1 trial suggests safety, tolerability and immunogenicity of a candidate subunit vaccine against the deadly Nipah virus, for which countermeasures are urgently needed.- November 26, 2025
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Nature Medicine, Published online: 26 November 2025; doi:10.1038/s41591-025-04072-0
Author Correction: Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets- November 26, 2025
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Nature Medicine, Published online: 25 November 2025; doi:10.1038/s41591-025-04050-6
The missing value of medical artificial intelligence- November 25, 2025
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Nature Medicine, Published online: 25 November 2025; doi:10.1038/s41591-025-04040-8
Our large-scale clustering analysis identifies four reproducible subtypes of polycystic ovary syndrome, which we validated across diverse populations. These subtypes have distinct reproductive and metabolic trajectories that could guide precision management strategies.- November 25, 2025
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Nature Medicine, Published online: 24 November 2025; doi:10.1038/s41591-025-03995-y
In this phase 1 trial, treatment of patients with fibrolamellar hepatocellular carcinoma with a therapeutic peptide vaccine targeting the fusion kinase DNAJB1–PRKACA, which is the driver of the disease, together with nivolumab and ipilimumab, was safe and led to encouraging preliminary clinical responses, and translational analysis showed activation of immune responses.- November 24, 2025
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As the natural colors market accelerates, natural ingredients industry leader Kalsec has just released a new global consumer report, focusing exclusively on how consumers perceive and purchase products with natural colors.
- November 21, 2025
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