Health

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Nature Medicine, Published online: 21 February 2025; doi:10.1038/s41591-025-03511-2

A cluster randomized trial in China shows that telemedicine-based, village doctor-led delivery of integrated care reduced the occurrence of adverse cardiovascular events and hospitalizations in older adults with atrial fibrillation.
  • February 21, 2025
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Nature Medicine, Published online: 21 February 2025; doi:10.1038/s41591-025-03499-9

A longitudinal multiomics analysis of a patient with multiple myeloma who developed peripheral T cell lymphoma after treatment with anti-BCMA CAR T cells and a GPRC5D-directed bispecific antibody reveals that two mutated CAR+CD8+ T cell clones were probably drivers of the neoplasm.
  • February 21, 2025
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Nature Medicine, Published online: 21 February 2025; doi:10.1038/d41591-025-00014-y

The phase 3 CheckMate 8HW trial shows superior outcomes with nivolumab plus ipilimumab (compared with nivolumab monotherapy) in patients with microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer.
  • February 21, 2025
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You may not be familiar with the term ‘ocimum tenuiflorum.’ It’s an aromatic plant that is widely used to manage health issues. More commonly known as Holy basil or tulsi, this is often used as a home remedy for cough. Rich in antioxidants, it can play a key role in boosting immunity. It is also …
  • February 20, 2025
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Having a difficult time pooping every morning or passing less than three stools a week? It must be because you are constipated. Consuming fibre-rich foods can make it easier to poop. Fruits, whole grains, legumes, and vegetables are clearly great sources of fibre, and can help you with your bowel movements. If you want to …
  • February 19, 2025
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Nature Medicine, Published online: 19 February 2025; doi:10.1038/s41591-024-03483-9

Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range of age-related diseases were compared, highlighting the potential beneficial effects of environment-focused interventions.
  • February 19, 2025
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Nature Medicine, Published online: 19 February 2025; doi:10.1038/s41591-024-03356-1

In a clinical trial in pregnant women with gestational diabetes, a dietary intervention for energy restriction was safe and did not result in any difference in maternal weight or offspring standardized birth weight outcomes compared to the control arm.
  • February 19, 2025
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Nature Medicine, Published online: 19 February 2025; doi:10.1038/s41591-025-03536-7

We leveraged early-pregnancy prenatal cell-free DNA screening (PDNAS) sequencing data to determine tissue signatures associated with the development of preeclampsia. Next, we used these epigenetic signatures, as informed by nucleosome positioning, to build machine learning models to classify preeclampsia risk that we validated in distinct internal and external cohorts.
  • February 19, 2025
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Nature Medicine, Published online: 19 February 2025; doi:10.1038/s41591-025-03552-7

Interventions focused on disease prevention are a promising strategy for combating the rising incidence of dementia, but more evidence from clinical trials is needed to establish their feasibility and effectiveness.
  • February 19, 2025
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Some U.S. schools are banning students from wearing Crocs to class. Officials say the loose-fitting shoes can cause accidents and injuries, while experts warn that unsupportive footwear may lead to posture issues and long-term bone problems.
  • February 18, 2025
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