Nature Medicine, Published online: 09 January 2026; doi:10.1038/s41591-025-04134-3
A protein biomarker, the NOTCH3 extracellular domain, identifies individuals with idiopathic pulmonary hypertension, correlates with disease progression, improves mortality risk prediction and provides a readily implementable, noninvasive blood test for this disease.- January 9, 2026
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Nature Medicine, Published online: 09 January 2026; doi:10.1038/s41591-025-04171-y
In a randomized, double-blind, placebo-controlled trial comparing autologous mRNA-engineered BCMA-targeting CAR T cell therapy versus placebo in patients with generalized myasthenia gravis, a significantly higher percentage of patients exhibited a reduction in disease activity in the treatment arm than in the placebo arm.- January 9, 2026
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Nature Medicine, Published online: 09 January 2026; doi:10.1038/s41591-025-04170-z
Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.- January 9, 2026
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Nature Medicine, Published online: 09 January 2026; doi:10.1038/s41591-025-04135-2
We have identified serum levels of extracellular domain of NOTCH3 (NOTCH3-ECD) as a biomarker that can reliably distinguish idiopathic pulmonary arterial hypertension from other forms of pulmonary hypertension and healthy controls. Our findings show that serum NOTCH3-ECD levels are as accurate as current standard-of-care clinical tests in predicting disease progression and mortality risk.- January 9, 2026
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Continue reading "Mace and nutmeg: Health benefits, risks, and how much you should really use"
- January 8, 2026
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Nature Medicine, Published online: 08 January 2026; doi:10.1038/s41591-025-04053-3
High-dimensional immune profiling of a living recipient of a pig-to-human xenotransplant provides insight into the immune landscape of xenotransplantation and directions for improved immunosuppression strategies.- January 8, 2026
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Nature Medicine, Published online: 08 January 2026; doi:10.1038/s41591-025-04090-y
In a randomized phase 2 trial in patients with acute coronary syndrome and high levels of the inflammation biomarker C-reactive protein, treatment with low-dose interleukin-2 increased the numbers of regulatory T cells and reduced arterial inflammation, compared to placebo.- January 8, 2026
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Nature Medicine, Published online: 08 January 2026; doi:10.1038/s41591-025-04122-7
China’s evidence-based re-evaluation of traditional Chinese medicine injections- January 8, 2026
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Laird Superfood has updated its Creamer with Lion’s Mane using organic coconut milk and organic vanilla extract. The refrigerated line now includes a caramel option and debuts packaging made with post-consumer recycled plastic.
- January 7, 2026
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Nature Medicine, Published online: 07 January 2026; doi:10.1038/s41591-025-04131-6
Clarification of evidence selection for the framework for the pharmacological treatment of obesity and its complications from the EASO- January 7, 2026
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