Nature Medicine, Published online: 23 April 2025; doi:10.1038/s41591-025-03647-1
Analysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combination immune checkpoint blockade, as well as delayed onset of immune-related adverse events across both treatment types, as well as delayed development of metastatic disease in seropositive patients.- April 23, 2025
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Nature Medicine, Published online: 23 April 2025; doi:10.1038/s41591-025-03726-3
The open-source DeepSeek large language model showed variable performance relative to two leading models when benchmarked on four different medical tasks, with relatively strong reasoning capabilities but similar or weaker relative performance on other tasks, such as summarization of imaging reports.- April 23, 2025
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This latest innovation provides bakers with a powerful, effective alternative to artificial preservatives, making it easier than ever to meet market demands for cleaner ingredient lists and extended freshness.
- April 22, 2025
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Nature Medicine, Published online: 22 April 2025; doi:10.1038/s41591-025-03624-8
Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.- April 22, 2025
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Nature Medicine, Published online: 22 April 2025; doi:10.1038/s41591-025-03656-0
Administration of an antisense oligonuceotide in a preterm infant with severe early-onset SCN2A developmental and epileptic encephalopathy was well tolerated and led to a 60% decrease in seizure frequency.- April 22, 2025
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Nature Medicine, Published online: 22 April 2025; doi:10.1038/s41591-025-03677-9
Microglia have a central role in the clearance of amyloid-β after immunotherapy in Alzheimer’s disease. By integrating spatial transcriptomics and single-cell RNA sequencing, we identified distinct microglial states that mediate removal of amyloid-β. APOE and TREM2 emerged as key regulators of amyloid-β clearance and indicators of treatment response, and thereby represent potential therapeutic targets.- April 22, 2025
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- April 21, 2025
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Nature Medicine, Published online: 21 April 2025; doi:10.1038/s41591-025-03616-8
In the CRHCP-3 cluster-randomized trial, blood pressure reduction lowered the risk of all-cause dementia by 15% in 33,995 individuals with hypertension.- April 21, 2025
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Nature Medicine, Published online: 18 April 2025; doi:10.1038/s41591-025-03645-3
The authors found, after analyzing 10,960 individuals from 9 multiancestry biobanks across 6 countries, that genetic factors previously associated with BMI have limited impact on GLP-1 receptor agonist-induced weight loss.- April 18, 2025
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Nature Medicine, Published online: 18 April 2025; doi:10.1038/s41591-025-03657-z
A multicohort study finds that social disadvantage is linked to proteomics signatures of aging, helping to explain the association between social disparities and more than 60 age-related diseases.- April 18, 2025
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