Health

Nature Medicine, Published online: 01 August 2025; doi:10.1038/s41591-025-03867-5

Five-year follow-up and prespecified exploratory biomarker analysis from the phase 3 KEYNOTE-426 trial show that pembrolizumab plus axitinib compared to sunitinib as first-line therapy continues to show overall and progression-free survival benefits in patients with advanced clear cell renal cell carcinoma and indicate that a T-cell-inflamed gene expression profile is predictive of response.

Nature Medicine, Published online: 01 August 2025; doi:10.1038/s41591-025-03862-w

Intravenous iron treatment lowers the risk of repeated hospitalizations for heart failure and cardiovascular death in patients with iron deficiency and heart failure with reduced left ventricular ejection fraction. The therapy has a good safety profile, and its benefits are most pronounced within the first year of treatment, when iron dosing is highest.

Nature Medicine, Published online: 01 August 2025; doi:10.1038/s41591-025-03904-3

Publisher Correction: Feasibility of multiomics tumor profiling for guiding treatment of melanoma

Nature Medicine, Published online: 31 July 2025; doi:10.1038/s41591-025-03849-7

Multimodal data from 347 deeply phenotyped individuals including healthy, prediabetic individuals and individuals with T2D report remotely acquired patterns of glucose control via continuous glucose monitoring, and correlates them with diet and microbiome features and physiological signals, showing that these are able to discriminate individuals with T2D from control also in a large independent cohort.

Nature Medicine, Published online: 31 July 2025; doi:10.1038/d41591-025-00048-2

A new analysis shows that more-permissive state-level firearm laws have contributed to thousands of excess firearm-related child deaths, while a few states enacting stricter laws have seen these death rates decrease.

Nature Medicine, Published online: 31 July 2025; doi:10.1038/s41591-025-03853-x

The phase 2 TUXEDO-3 trial identifies the HER3-targeting antibody–drug conjugate patritumab deruxtecan as a promising new therapeutic option for patients with leptomeningeal metastasis from solid tumors.

Nature Medicine, Published online: 30 July 2025; doi:10.1038/d41591-025-00047-3

For women carrying pathogenic mitochondrial DNA variants, a novel technique — involving transfer of their nuclear DNA to an enucleated donor egg — resulted in successful pregnancies and healthy children.

Nature Medicine, Published online: 30 July 2025; doi:10.1038/s41591-025-03869-3

Key drivers for mpox control at its source to reduce costs amid aid cuts to Africa

Nature Medicine, Published online: 30 July 2025; doi:10.1038/s41591-025-03860-y

Single-cell transcriptomic profiling of immune cells in the blood and liver of a human decedent receiving a pig liver xenograft reveals impaired adaptive immunity and monocyte features that may induce T cell exhaustion and contribute to platelet activation.

Nature Medicine, Published online: 30 July 2025; doi:10.1038/s41591-025-03836-y

DeepSeek’s potential for on-premises deployment in hospitals reveals a regulatory ‘gray area’ that requires enhanced guidance.