Nature Medicine, Published online: 14 July 2025; doi:10.1038/s41591-025-03801-9
This Review discusses the scientific and technological breakthroughs reshaping transplant medicine, with a focus on the transformative role of artificial intelligence, xenotransplantation and tissue engineering as new sources of organs, and novel approaches to immunosuppression.- July 14, 2025
- 0 Comment
Nature Medicine, Published online: 14 July 2025; doi:10.1038/s41591-025-03855-9
Transplantation of pig kidneys into patients is entering clinical trials, but important scientific questions need to be addressed before kidney xenotransplantation can become an everyday clinical reality.- July 14, 2025
- 0 Comment
With the global gummy supplement category projected to more than double in size by 2030 to US $52.2 billion[i] and nearly two-thirds of U.S adults now favor gummies over tablets[ii] Jungbunzlauer's offer reflects the shifting preferences shaping this rapidly expanding category.
- July 11, 2025
- 0 Comment
Nature Medicine, Published online: 11 July 2025; doi:10.1038/s41591-025-03784-7
The antisense oligonucleotide rugonersen has acceptable safety and tolerability in children with Angelman syndrome and shows partial normalization of electroencephalogram abnormalities and clinical improvements relative to natural history.- July 11, 2025
- 0 Comment
Nature Medicine, Published online: 10 July 2025; doi:10.1038/s41591-025-03830-4
In a phase 1 trial, treatment of individuals with mixed hyperlipidemia with a monoclonal antibody targeting the angiopoietin-like protein 3/8 complex resulted in dose-dependent reductions in the levels of triglycerides and low-density lipoprotein cholesterol, while increasing the levels of high-density lipoprotein.- July 10, 2025
- 0 Comment
Nature Medicine, Published online: 10 July 2025; doi:10.1038/s41591-025-03792-7
In the dose-expansion cohort of this phase 1b trial, the EGFR×HER3 bispecific antibody–drug conjugate BL-B01D1 given to patients with metastatic esophageal squamous cell carcinoma led to encouraging clinical response rates, which need to be confirmed in larger efficacy trials.- July 10, 2025
- 0 Comment
Nature Medicine, Published online: 10 July 2025; doi:10.1038/s41591-025-03803-7
A single-cell-resolution reference atlas of circulating hematopoietic stem and progenitor cells from healthy people reveals variations in cell-population frequencies and transcriptional profiles associated with age and sex. This atlas enables non-invasive diagnosis, risk stratification and follow-up of hematological conditions using peripheral blood, offering a potential alternative to bone marrow sampling.- July 10, 2025
- 0 Comment
Nature Medicine, Published online: 09 July 2025; doi:10.1038/s41591-025-03798-1
In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong predictors of healthspan and longevity.- July 9, 2025
- 0 Comment
Nature Medicine, Published online: 09 July 2025; doi:10.1038/s41591-025-03780-x
In a silent trial involving 197 patients with lung cancer over a span of 4 months, a fine-tuned pathology foundation model was able to identify the presence of EGFR mutations with high accuracy, potentially preventing further genetic testing in 43% of cases.- July 9, 2025
- 0 Comment
Nature Medicine, Published online: 08 July 2025; doi:10.1038/s41591-025-03791-8
Siltartoxatug, a first-in-class recombinant monoclonal antibody for tetanus prophylaxis, was shown to be safe and superior to plasma-derived human tetanus immunoglobulin in achieving anti-tetanus neutralizing antibody titers 12 hours after administration.- July 8, 2025
- 0 Comment
