Health

Nature Medicine, Published online: 03 November 2025; doi:10.1038/s41591-025-03955-6

In cognitively normal older adults at risk for Alzheimer’s dementia, physical inactivity was associated with faster tau protein buildup and cognitive decline.

Nature Medicine, Published online: 03 November 2025; doi:10.1038/s41591-025-04028-4

Shorena Janelidze recalls the discovery of phosphorylated tau, from early lab work to clinical implementation.

Nature Medicine, Published online: 31 October 2025; doi:10.1038/s41591-025-04020-y

A new study expands the utility of the gold-standard ferret model to assess the risks that are associated with consuming raw milk and cheese contaminated with influenza A virus — marking an important step toward improving risk assessments in public health.

Nature Medicine, Published online: 31 October 2025; doi:10.1038/s41591-025-04021-x

Africa’s continental plan to end cholera

Nature Medicine, Published online: 29 October 2025; doi:10.1038/s41591-025-04036-4

We show that clinically accredited genomic newborn screening can be delivered with short turnaround times, detects many more conditions than standard newborn screening, and is both clinically impactful and highly acceptable to families.

Nature Medicine, Published online: 29 October 2025; doi:10.1038/s41591-025-04026-6

Academic freedom and meaningful international cooperation are needed to safeguard good health and well-being globally

Nature Medicine, Published online: 29 October 2025; doi:10.1038/s41591-025-04063-1

Author Correction: Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding

Nature Medicine, Published online: 29 October 2025; doi:10.1038/s41591-025-04064-0

Author Correction: Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis

According to the U.S. Centers for Disease Control and Prevention (CDC), the risk of car crashes is higher among teens ages 16–19 than in any other age group. Teen drivers have a fatal crash rate almost three times as high as drivers ages 20 and older for every mile driven.

Nature Medicine, Published online: 28 October 2025; doi:10.1038/s41591-025-04039-1

We found that adults carrying melanocortin 4 receptor (MC4R) mutations had lower levels of low-density lipoprotein cholesterol, lower triglyceride levels and reduced cardiovascular disease risk than adults without mutations, despite severe obesity. We show that brain MC4Rs regulate lipid metabolism in humans, highlighting potential therapeutic approaches for cardiovascular risk reduction.