Health

Nature Medicine, Published online: 03 February 2026; doi:10.1038/s41591-025-04184-7

To function safely and effectively, medical AI models must adapt automatically to differences in users, health systems, geographies, diseases and populations. This Perspective proposes context switching as the defining paradigm of medical AI, outlining early strategies and opportunities for development.

Nature Medicine, Published online: 03 February 2026; doi:10.1038/s41591-025-04193-6

The phase 2/3 DEVOTE trial demonstrated that high-dose nusinersen significantly improved motor function and was safe in patients with spinal muscular atrophy, compared with a matched sham control.

Nature Medicine, Published online: 03 February 2026; doi:10.1038/s41591-026-04199-8

The promise was global. The fracture, when it came, was painfully local.

Feeling like your family’s money doesn’t go as far as it used to? The U.S. Bureau of Labor Statistics’ latest Consumer Expenditure Survey shows that the yearly food budget for the average American home exceeded $10,000, or about $27 a day, for the first time in 2024. Of that amount, $6,224 was spent on food eaten at home (an increase of 2.8 percent from 2023), while $3,945 was spent eating out.

Nature Medicine, Published online: 02 February 2026; doi:10.1038/s41591-025-04181-w

In this randomized phase 3 trial, patients with treatment-naive stage III–IV nonsmall cell lung cancer who received sintilimab or pembrolizumab in combination with chemotherapy early in the day (before 15:00 h) experienced longer progression-free survival compared with those receiving late time-of-day infusions.

Nature Medicine, Published online: 02 February 2026; doi:10.1038/s41591-025-04156-x

A WHO-supported pre−post study shows that implementation of the Y-Check comprehensive health check program is feasible and acceptable for adolescents in Zimbabwe, offering screening for 25 health conditions and behaviors, health promotion, on-site care and referral.

Nature Medicine, Published online: 02 February 2026; doi:10.1038/s41591-026-04200-4

In low- and middle-income countries (LMICs), adolescents have limited access to healthcare. A study in urban Zimbabwe demonstrated that routine check-up visits integrated within existing school and healthcare systems are feasible and acceptable. The check-up intervention showed potential for improving health and educational outcomes, as well as the long-term well-being of adolescents.

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Nature Medicine, Published online: 30 January 2026; doi:10.1038/d41591-026-00005-7

Using a new approach to control for genetic and environmental confounders, a review and meta-analysis finds no link between paracetamol use during pregnancy and neurodevelopmental outcomes in children.

Nature Medicine, Published online: 30 January 2026; doi:10.1038/d41591-026-00004-8

In patients with T cell acute lymphoblastic leukemia, base-edited CAR T cells — capable of destroying leukemic T cells while they themselves are protected — induced remission and allowed progression to stem-cell transplantation.