Health

Nature Medicine, Published online: 15 October 2025; doi:10.1038/s41591-025-04034-6

A multi-center, hospital-based observational study in India evaluated the effectiveness of Rotavac, a locally produced rotavirus vaccine, against laboratory-confirmed rotavirus gastroenteritis in children under 5 years of age. Vaccine effectiveness was stratified by age and viral genotype, and vaccine impact was assessed through comparisons of rotavirus positivity before and after Rotavac was introduced in the national immunization program.

The U.S. Centers for Disease Control and Prevention launched its “Free Mind” campaign in July to help people between the ages of 12 and 17 educate themselves about the link between substance abuse and mental health. The campaign materials, accessible at https://www.cdc.gov/free-mind, offer resources like advice from teen peers, informational videos, in-depth fact sheets, conversation starters, and tips for parents and caregivers. There’s even an interactive graphic novel you can play like a video game! As Dr. Allison Arwady, Director of the CDC National Center for Injury Prevention and Control, says, “Talking openly about mental health and substance use, and knowing when to get professional help, is critical to helping teens stay healthy.”

Nature Medicine, Published online: 14 October 2025; doi:10.1038/s41591-025-03992-1

A working group of Academia Europaea proposes the addition of a ‘ring diagram’ in clinical publications for the quick evaluation of translational implications.

Nature Medicine, Published online: 14 October 2025; doi:10.1038/s41591-025-04007-9

Strengthening medical imaging capacity will save lives

Nature Medicine, Published online: 10 October 2025; doi:10.1038/s41591-025-03985-0

Malaria parasites that evade the most widely used rapid diagnostic tests are spreading. We combined new data and modeling to pinpoint global hotspots at risk for these diagnostic-resistant parasites and to guide surveillance and contingency plans.

Nature Medicine, Published online: 10 October 2025; doi:10.1038/s41591-025-03987-y

Two phase 1 studies report promising outcomes with chimeric antigen receptor (CAR) T cell therapies in patients with systemic lupus erythematosus, but the next stage of development must address key pitfalls around comparator arms and ancillary immune-modulating treatments.

Nature Medicine, Published online: 10 October 2025; doi:10.1038/s41591-025-04005-x

Three studies that leverage blood-based gene expression data identify molecular and cellular host response signatures in sepsis and critical illnesses, opening a pathway to mechanism-anchored precision therapy.

Nature Medicine, Published online: 10 October 2025; doi:10.1038/s41591-025-04033-7

We call for more studies exploring the implementation of AI technologies and what happens when humans and AI interact in the clinic.

Nature Medicine, Published online: 09 October 2025; doi:10.1038/s41591-025-03986-z

The BabyScreen+ study offered genomic screening to 1,000 newborns in Australia, and showed that the approach is feasible and positively received by families, leading to molecular diagnoses in 1.6% of babies.

Nature Medicine, Published online: 09 October 2025; doi:10.1038/s41591-025-04000-2

A clinical trial of pregnant women provides critical safety and immunogenicity data in support of a two-dose Ebola vaccine regimen — and reinforces the importance of maternal immunization research, urgently needed for other preventable diseases.