News

Nature Medicine, Published online: 26 June 2025; doi:10.1038/s41591-025-03810-8

We developed CANSCAN, a blood test that analyzes multidimensional features of cell-free DNA (cfDNA) using whole-genome sequencing (WGS) and artificial intelligence (AI) models. This multi-cancer early detection (MCED) test demonstrates high sensitivity for early-stage cancers and accurate tissue-of-origin prediction in large prospective validation and asymptomatic screening cohorts.

Nature Medicine, Published online: 26 June 2025; doi:10.1038/s41591-025-03797-2

Jeffrey Friedman recalls the heady excitement when his group discovered leptin, a hormone that regulates appetite.

Nature Medicine, Published online: 26 June 2025; doi:10.1038/s41591-025-03825-1

To capture the changing rather than one-off risk of type 1 diabetes (T1D), we developed an artificial intelligence-driven microRNA-based multi-context (5,983 samples from 7 countries) dynamic risk score (DRS). We validated that this DRS enabled T1D discrimination, misdiagnosis correction and therapeutic response prediction, establishing a personalized, adaptive framework for T1D risk monitoring and intervention.

In London, an actor playing Evita sings "Don't Cry for Me, Argentina" from a balcony over the street. It's livestreamed back into the theater – frustrating ticket holders but delighting the public.

The American Black Film Festival (ABFF) made a dynamic return to Miami Beach, delivering five electrifying days that celebrated the power of Black artistry and storytelling.

The post Lights, Camera, Legacy! The American Black Film Festival Turns 29 With A Star-Studded Celebration In Miami appeared first on MadameNoire.

A 50-year-old TikToker's plastic surgery procedure is raising eyebrows—and not just hers. Michelle Wood started documenting her journey under the knife in early June, sharing on TikTok that she...

Tate Madden is willing to accept Tyler Cameron’s rose—thorns and all. Nearly a year after the Bachelor Nation alum confirmed his new relationship, his girlfriend shared her thoughts on being...

Ciara is making it known that any beef she once had with Rihanna is…well…done.

The post Ciara Clears The Air On Her ‘Feud’ With Rihanna: ‘We Were Babies’ appeared first on MadameNoire.

Nature Medicine, Published online: 25 June 2025; doi:10.1038/s41591-025-03776-7

In a reverse-translational study followed by a clinical trial, the targeting of antigen-presenting mast cells was identified as a therapeutic approach to overcome anti-PD-1 resistance in patients with metastatic triple-negative breast cancer who experienced clinical benefit when treated with the mast cell stabilizer cromolyn.

Nature Medicine, Published online: 25 June 2025; doi:10.1038/s41591-025-03771-y

Using mathematical models calibrated to clinical trial results on vaccine efficacy, this study projects the potential impact of the vaccine at population level, showing the conditions for it to be effective in reducing cases and hospitalizations and helping to design vaccination campaigns.