CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade
Nature Medicine, Published online: 23 April 2025; doi:10.1038/s41591-025-03647-1
Analysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combination immune checkpoint blockade, as well as delayed onset of immune-related adverse events across both treatment types, as well as delayed development of metastatic disease in seropositive patients.
CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade
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