Cytokine-mediated CAR T therapy resistance in AML
Nature Medicine, Published online: 27 September 2024; doi:10.1038/s41591-024-03271-5
In a phase 1 trial followed by translational analyses, patients with acute myeloid leukemia (AML) treated with chimeric antigen receptor (CAR) T cell therapy targeting CD123 experienced high levels of cytokine release syndrome and short-lived clinical responses, probably due to CAR T cell-derived cytokines increasing the viability of AML blasts and antigen persistence.
Cytokine-mediated CAR T therapy resistance in AML
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