Domvanalimab and zimberelimab in advanced gastric, gastroesophageal junction or esophageal cancer: a phase 2 trial
Nature Medicine, Published online: 18 October 2025; doi:10.1038/s41591-025-04022-w
As presented at the ESMO Congress 2025: in this international, single-arm phase 2 trial, first-line treatment of patients with advanced gastric cancer, gastroesophageal junction cancer or esophageal adenocarcinoma with domvanalimab (Fc-silent anti-TIGIT) and zimberelimab (anti-PD-1) plus FOLFOX (oxaliplatin, leucovorin and fluorouracil) led to encouraging objective response rates and survival outcomes, which will be validated in a phase 3 trial.
Domvanalimab and zimberelimab in advanced gastric, gastroesophageal junction or esophageal cancer: a phase 2 trial
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