Endothelial cell-mediated risk of CAD could be used to target lipid-lowering therapy
Nature Medicine, Published online: 04 March 2025; doi:10.1038/s41591-025-03553-6
We developed an endothelial cell-specific polygenic risk score for coronary artery disease (CAD), which quantifies a currently immeasurable axis of CAD risk. This tool identifies patients who are more susceptible to LDL-C entering the cell wall and will benefit from aggressive lipid-lowering therapy, providing an opportunity to guide earlier and more-personalized preventive therapies.
Endothelial cell-mediated risk of CAD could be used to target lipid-lowering therapy
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