High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity
Nature Medicine, Published online: 20 September 2024; doi:10.1038/s41591-024-03224-y
A single-cell ex vivo screening of repurposable drugs in glioblastoma and machine learning of drug–target networks show that anti-tumor neuroactive drugs converge on the AP-1/BTG pathway, based on which prediction models and experimental in vivo and in silico validation identify the anti-depressant vortioxetine as a potential therapeutic agent.
High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity
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