HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation
Nature Medicine, Published online: 27 February 2023; doi:10.1038/s41591-023-02215-9
We describe a 53-year-old man with HIV-1 who received allogeneic CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) in 2013 to treat acute myeloid leukemia. Four years after analytic treatment interruption (ATI), the absence of viral rebound and the lack of immunological correlates of HIV-1 antigen persistence provide convincing evidence for HIV-1 cure.
HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation
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