Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade
Nature Medicine, Published online: 27 January 2026; doi:10.1038/s41591-025-04177-6
Transcriptomic and clinical data analyses from multiple cohorts of patients with cancer receiving immunotherapy find that PD-1 blockade potentiates tumor-specific IgG1 plasma cell responses that complement cellular immunity and contribute to clinical benefit.
Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade
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