Identification of distinct types of steatotic liver disease with specific clinical trajectories

Identification of distinct types of steatotic liver disease with specific clinical trajectories

Nature Medicine, Published online: 09 December 2024; doi:10.1038/s41591-024-03366-z

In a cluster analysis study, we identified two types of metabolic dysfunction-associated steatotic liver disease (MASLD) characterized by distinct clinical trajectories. The two types of MASLD show similar liver histology, but one is liver-specific with low cardiovascular risk while the other has high cardiovascular risk and high metabolic risk.

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Identification of distinct types of steatotic liver disease with specific clinical trajectories

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