In vivo base editing extends lifespan of a humanized mouse model of prion disease
Nature Medicine, Published online: 14 January 2025; doi:10.1038/s41591-024-03466-w
An in vivo base editing approach targeting the PRNP gene led to a 52% increase in the lifespan of mouse models inoculated with the most common sporadic and genetic types of human pathogenic prion isolate.
In vivo base editing extends lifespan of a humanized mouse model of prion disease
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