Influenza vaccine strain selection with an AI-based evolutionary and antigenicity model

Influenza vaccine strain selection with an AI-based evolutionary and antigenicity model

Nature Medicine, Published online: 28 August 2025; doi:10.1038/s41591-025-03917-y

By matching antigenicity prediction with a forecast of circulating strains in the next season, a model is shown to outperform standard recommendations for vaccine design in terms of vaccine effectiveness and disease burden in multiple evaluations throughout different influenza seasons.

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Influenza vaccine strain selection with an AI-based evolutionary and antigenicity model

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