Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma
Nature Medicine, Published online: 05 June 2025; doi:10.1038/s41591-025-03699-3
In this genomic analysis of peripheral blood samples of the phase 3 CheckMate-067 trial of ipilimumab (IPI) versus nivolumab (NIVO) versus ipilimumab and nivolumab (IPI-NIVO) in melanoma, the status of certain mitochondrial haplogroups in patients was associated therapeutic resistance to NIVO or IPI-NIVO, a finding validated in an independent cohort.
Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma
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