Low cholesterol levels and cardiovascular risk in obesity due to MC4R deficiency
Nature Medicine, Published online: 28 October 2025; doi:10.1038/s41591-025-04039-1
We found that adults carrying melanocortin 4 receptor (MC4R) mutations had lower levels of low-density lipoprotein cholesterol, lower triglyceride levels and reduced cardiovascular disease risk than adults without mutations, despite severe obesity. We show that brain MC4Rs regulate lipid metabolism in humans, highlighting potential therapeutic approaches for cardiovascular risk reduction.
Low cholesterol levels and cardiovascular risk in obesity due to MC4R deficiency
| Divisions of Shy Paris Entertainment | ||||
|---|---|---|---|---|
| Shyparis Entertainment | Shy Paris Bookings | Linkz Radio | Klublinks | Shy Paris |
Shy Paris Bookings is a Division of
❤Shy Paris Entertainment ||||| International Spectacular Events, Stellar Event Planning and Management, & Celebrity Booking Agency. Please contact us as we can provide you with both international and/or local renowned full service event planning and management, & celebrity bookings at shyparisentertainment@gmail.com or
CONTACT: Email: shyparisentertainment@gmail.com
Facebook: ShyParis Youtube: @Shyparis Twitter: @Shyparisent Instagram: shyparisentertainment Whatsapp: 1-437-259-3399
✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶✶
SHY PARIS ENTERTAINMENT COMPANIES
✅ ShyParisentertainment.co – https://shyparisentertainment.co
✅ Shyparisbookings.com – https://shyparisbookings.com
✅ Linkzradio.com – https://linkzradio.com
✅ Klublinks.com – https://klublinks.com
✅ Shypariswebdesign.com – https://shypariswebdesign.com
✅ ❤️ Shyparis – htttps://shyparis.com❤️
