Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results
Nature Medicine, Published online: 11 August 2025; doi:10.1038/s41591-025-03876-4
In the final analysis of a phase 1 trial evaluating a lymph node-targeting mutant KRAS peptide vaccine combined with CpG in the adjuvant setting for patients with KRAS mutant pancreatic or colorectal cancer, median relapse-free survival and overall survival were not reached for patients with robust antigen-specific T cell responses, and these responses were durable with evidence of antigen spreading.
Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results
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