Mapping circulating hematopoietic stem cells for non-invasive, blood-based diagnostics
Nature Medicine, Published online: 10 July 2025; doi:10.1038/s41591-025-03803-7
A single-cell-resolution reference atlas of circulating hematopoietic stem and progenitor cells from healthy people reveals variations in cell-population frequencies and transcriptional profiles associated with age and sex. This atlas enables non-invasive diagnosis, risk stratification and follow-up of hematological conditions using peripheral blood, offering a potential alternative to bone marrow sampling.
Mapping circulating hematopoietic stem cells for non-invasive, blood-based diagnostics
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