Mapping metastatic breast cancer complexity through single-cell and spatial profiling
Nature Medicine, Published online: 30 October 2024; doi:10.1038/s41591-024-03308-9
Techniques for single-cell and spatial expression profiling hold great promise for defining the complexity of metastatic microenvironments, but different methods give different representations. We profile 67 biopsies of metastatic breast cancer using up to 6 different methods, provide a systematic comparison and reveal spatial aspects of breast cancer biology across diverse clinicopathological features.
Mapping metastatic breast cancer complexity through single-cell and spatial profiling
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