Microglia drive amyloid-β clearance in immunized patients with Alzheimer’s disease
Nature Medicine, Published online: 22 April 2025; doi:10.1038/s41591-025-03677-9
Microglia have a central role in the clearance of amyloid-β after immunotherapy in Alzheimer’s disease. By integrating spatial transcriptomics and single-cell RNA sequencing, we identified distinct microglial states that mediate removal of amyloid-β. APOE and TREM2 emerged as key regulators of amyloid-β clearance and indicators of treatment response, and thereby represent potential therapeutic targets.
Microglia drive amyloid-β clearance in immunized patients with Alzheimer’s disease
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