Modeling multiple myeloma heterogeneity in mice to advance therapeutic discoveries
Nature Medicine, Published online: 15 March 2023; doi:10.1038/s41591-022-02198-z
To meet a current unmet medical need, we generated 15 genetically engineered mouse models that accurately reflect the key pathogenetic aspects of human multiple myeloma. By coupling mechanistic investigations and pre-clinical immunotherapy testing, these pre-clinical platforms provide knowledge that will aid the optimization of future immunotherapy clinical trial design.
Modeling multiple myeloma heterogeneity in mice to advance therapeutic discoveries
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