Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis

Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis

Nature Medicine, Published online: 20 October 2025; doi:10.1038/s41591-025-04014-w

Myelin damage in multiple sclerosis can be detected up to 7 years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis.

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Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis

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