Persistent mutation burden drives sustained anti-tumor immune responses

Persistent mutation burden drives sustained anti-tumor immune responses

Nature Medicine, Published online: 26 January 2023; doi:10.1038/s41591-022-02163-w

Genomic analyses in large cohorts of patients with cancer identify a new measure of tumor mutational burden, based on genomic regions that are unlikely to undergo loss, that is associated with therapeutic response to immunotherapy.

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Persistent mutation burden drives sustained anti-tumor immune responses

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