health

Nature Medicine, Published online: 25 January 2025; doi:10.1038/s41591-024-03443-3

As presented at the 2025 ASCO GI Cancers Symposium: in the phase 3 BREAKWATER trial, patients with previously untreated BRAF V600E metastatic colorectal cancer received the BRAF inhibitor encorafenib, the anti-EGFR monoclonal antibody cetuximab and chemotherapy mFOLFOX6 versus investigator’s choice of chemotherapy with or without bevacizumab, leading to an improved objective response rate, with the dual primary endpoint of progression free survival still maturing.

Black coffee, a popular beverage recognised for its rich aroma and stimulating characteristics, has become a modern-day staple. It has several benefits, including increased alertness and cognitive performance. But have you tried drinking black coffee for weight loss? Caffeine, the primary component in coffee, can boost your metabolism, resulting in more calorie burning. It can …

Continue reading "Black coffee for weight loss: 3 ways it can get you back in shape"

Nature Medicine, Published online: 24 January 2025; doi:10.1038/s41591-024-03430-8

In two independent cohorts of Ugandan children with severe malaria, elevated blood uric acid was found to be common and linked to both acute and postdischarge mortality, as well as poorer long-term cognitive outcomes.

Nature Medicine, Published online: 24 January 2025; doi:10.1038/s41591-024-03486-6

This proof-of-concept phase 1 trial shows that the size of circulating tumor cell clusters (which can promote metastatic spread) can be reduced by treatment with the Na+/K+ ATPase inhibitor digoxin in patients with metastatic breast cancer.

Nature Medicine, Published online: 24 January 2025; doi:10.1038/s41591-025-03521-0

Author Correction: Propagative α-synuclein seeds as serum biomarkers for synucleinopathies

Tired of eating cauliflower and cabbage almost every day? Go for their close relative – Brussels sprouts, which also belong to the cruciferous family. The ball shaped vegetable looks like a smaller version of cabbage. Even though it is small in size, the green-coloured vegetable is a nutrient-dense food. Loaded with nutrients like vitamin C, …

Continue reading "Brussels sprouts benefits: 9 reasons to have this cruciferous vegetable"

Nature Medicine, Published online: 23 January 2025; doi:10.1038/s41591-024-03476-8

This study systematically analyzed 175 health outcomes in 2 million people using glucagon-like peptide-1 receptor agonists (GLP-1RAs) or other antihyperglycemics. GLP-1RAs reduce risks of neurocognitive, substance use, cardiovascular and respiratory disorders, but increase risks of gastrointestinal issues, hypotension and pancreatitis. The study provides important insights for clinical practice and future research.

Nature Medicine, Published online: 23 January 2025; doi:10.1038/s41591-024-03436-2

Brian J. Druker describes how his research on imatinib validated protein kinases as therapeutic targets for cancer and led to a life-saving treatment for leukemia.

Nature Medicine, Published online: 22 January 2025; doi:10.1038/s41591-024-03450-4

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Nature Medicine, Published online: 22 January 2025; doi:10.1038/s41591-024-03446-0

Announced in this Comment and in collaboration with Nature Medicine is the convening of the Quality Health Information for All Commission, to promote equitable access to quality health information from trusted sources and affirm the practice of health communication as a distinct public health discipline.