health

Nature Medicine, Published online: 10 October 2025; doi:10.1038/s41591-025-03985-0

Malaria parasites that evade the most widely used rapid diagnostic tests are spreading. We combined new data and modeling to pinpoint global hotspots at risk for these diagnostic-resistant parasites and to guide surveillance and contingency plans.

Nature Medicine, Published online: 10 October 2025; doi:10.1038/s41591-025-03987-y

Two phase 1 studies report promising outcomes with chimeric antigen receptor (CAR) T cell therapies in patients with systemic lupus erythematosus, but the next stage of development must address key pitfalls around comparator arms and ancillary immune-modulating treatments.

Nature Medicine, Published online: 10 October 2025; doi:10.1038/s41591-025-04005-x

Three studies that leverage blood-based gene expression data identify molecular and cellular host response signatures in sepsis and critical illnesses, opening a pathway to mechanism-anchored precision therapy.

Nature Medicine, Published online: 10 October 2025; doi:10.1038/s41591-025-04033-7

We call for more studies exploring the implementation of AI technologies and what happens when humans and AI interact in the clinic.

Nature Medicine, Published online: 09 October 2025; doi:10.1038/s41591-025-03986-z

The BabyScreen+ study offered genomic screening to 1,000 newborns in Australia, and showed that the approach is feasible and positively received by families, leading to molecular diagnoses in 1.6% of babies.

Nature Medicine, Published online: 09 October 2025; doi:10.1038/s41591-025-04000-2

A clinical trial of pregnant women provides critical safety and immunogenicity data in support of a two-dose Ebola vaccine regimen — and reinforces the importance of maternal immunization research, urgently needed for other preventable diseases.

Nature Medicine, Published online: 08 October 2025; doi:10.1038/s41591-025-04003-z

In a randomized, placebo-controlled, stepwise dose-escalation phase 1 trial evaluating a conjugate vaccine against both typhoid and invasive non-typhoidal Salmonella infections, the vaccine was found to be safe and immunogenic in healthy adults.

Nature Medicine, Published online: 08 October 2025; doi:10.1038/s41591-025-04010-0

The pathogenic avian flu H5N1 virus remains stable in raw milk and throughout the cheese-making process, but contaminated cheese fed to ferrets did not lead to infection, whereas raw milk did.

Nature Medicine, Published online: 08 October 2025; doi:10.1038/s41591-025-03981-4

This prespecified updated survival and exploratory subgroup efficacy analysis of the phase 3 DESTINY-Breast04 trial shows that trastuzumab deruxtecan treatment in patients with HER2-low metastatic breast cancer leads to continuous survival benefit irrespective of estrogen receptor or hormone receptor status.

Nature Medicine, Published online: 08 October 2025; doi:10.1038/s41591-025-03943-w

Results from the randomized, noncomparative, phase 2 MATISSE trial show that ultra-short neoadjuvant therapy with ipilimumab and nivolumab can prevent surgery and radiotherapy in patients with resectable cutaneous squamous cell carcinoma, with an early decrease in total lesion glycolysis by [18F]FDG-PET/CT associated with response.