health

Nature Medicine, Published online: 27 February 2025; doi:10.1038/s41591-025-03512-1

A patient with newly diagnosed glioblastoma was safely treated with neoadjuvant nivolumab, relatlimab and ipilimumab before maximal resection, with comprehensive immune profiling showing the induction of overall immune activation early during treatment. The patient had no definitive evidence of recurrence at 17 months after treatment.

Nature Medicine, Published online: 27 February 2025; doi:10.1038/s41591-025-03538-5

Cerebrospinal fluid circulating tumor DNA profiling had prognostic value in a cohort of 584 patients with lung cancer and central nervous system metastases, and could be used to inform personalized therapies.

Nature Medicine, Published online: 27 February 2025; doi:10.1038/s41591-025-03530-z

Multi-omic single-cell and spatial analyses of lung cancer brain metastases from multiple cohorts identify high levels of chromosomal instability and a neural-like profile in brain metastases compared with primary tumors.

Nature Medicine, Published online: 26 February 2025; doi:10.1038/s41591-025-03533-w

From an analysis of participants in lipid-lowering trials for primary and secondary prevention of coronary artery disease, a polygenic risk score comprising 35 single nucleotide variants with predicted effects on endothelial cell function identified patients who benefited most from aggressive lipid-lowering therapy.

Nature Medicine, Published online: 26 February 2025; doi:10.1038/d41591-025-00016-w

A machine learning framework — trained on B cell and T cell receptor sequences from thousands of people — can detect a range of infectious and autoimmune diseases.

Nature Medicine, Published online: 26 February 2025; doi:10.1038/s41591-025-03550-9

How to measure biological aging in humans

Nature Medicine, Published online: 25 February 2025; doi:10.1038/d41591-025-00015-x

In a phase 2 registrational trial, zenocutuzumab showed durable anti-tumor activity across a variety of NRG1 fusion-positive cancer types, providing a new treatment for patients with few alternative options.

Nature Medicine, Published online: 25 February 2025; doi:10.1038/s41591-025-03583-0

A sustained decrease in low-density lipoprotein cholesterol (LDL-C) is key to reducing the risk of atherosclerotic cardiovascular disease; however, achieving this goal can be hampered by low adherence to standard of care and the sub-maximal efficacy of currently available long-acting therapeutics. We developed an epigenetic editor that targets PCSK9 and robustly and durably decreases LDL-C.

A recent study in the research journal PNAS Nexus suggests that shutting off smartphone Internet for two weeks can improve happiness and well-being. Researchers followed 467 study participants and found they felt more focused and less stressed without constant online access on their phones.

Nature Medicine, Published online: 24 February 2025; doi:10.1038/s41591-025-03502-3

Global analyses of breast cancer incidence and mortality show that only seven high-income countries are currently meeting the targets of the World Health Organization Global Breast Cancer Initiative in reducing the rate of breast cancer mortality by 2.5% per year, but cases and deaths are increasing and disproportionately affecting countries with low Human Development Index.