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Nature Medicine, Published online: 21 April 2025; doi:10.1038/s41591-025-03616-8

In the CRHCP-3 cluster-randomized trial, blood pressure reduction lowered the risk of all-cause dementia by 15% in 33,995 individuals with hypertension.

Nature Medicine, Published online: 18 April 2025; doi:10.1038/s41591-025-03590-1

Helmholtz Health task force to strengthen prevention research and its translation globally

Nature Medicine, Published online: 18 April 2025; doi:10.1038/s41591-025-03645-3

The authors found, after analyzing 10,960 individuals from 9 multiancestry biobanks across 6 countries, that genetic factors previously associated with BMI have limited impact on GLP-1 receptor agonist-induced weight loss.

Nature Medicine, Published online: 18 April 2025; doi:10.1038/s41591-025-03657-z

A multicohort study finds that social disadvantage is linked to proteomics signatures of aging, helping to explain the association between social disparities and more than 60 age-related diseases.

Nature Medicine, Published online: 17 April 2025; doi:10.1038/d41591-025-00026-8

Despite a negative primary outcome, a trial of gantenerumab showed a clinically meaningful slowing of disease onset in asymptomatic people who were treated for the longest duration.

Nature Medicine, Published online: 17 April 2025; doi:10.1038/s41591-025-03673-z

An AI-driven screener for opioid use disorder in hospital settings could increase referrals to addiction services and improve patient outcomes, but it is crucial that treatment is accessible and that unintended harms such as stigma are avoided.

Nature Medicine, Published online: 17 April 2025; doi:10.1038/s41591-025-03718-3

In a patient with treatment-refractory idiopathic inflammatory myositis, re-infusion of CD19 CAR-T cells following disease relapse led to the development of anti-CD19 CAR T cells and no clinical improvement, with drug-free remission induced again after treatment with BCMA CAR-T cells

According to data released this month by the Centers for Disease Control and Prevention (CDC), the rate of autism among eight year olds in the U.S. reached a record high in 2022. Based on a study made in 14 states and Puerto Rico, the condition was found to affect 1 in every 31 children, up from 1 in 36 in 2020 and 1 in 44 in 2018. Researchers believe that the increase is influenced by changes in autism screening and diagnosis, but according to Walter Zahorodny, a co-author of study, the real challenge is determining its underlying cause. “The problem is there‘s not a lot of research that gives us a strong indication for what is driving the rise,” he said.

Nature Medicine, Published online: 16 April 2025; doi:10.1038/s41591-025-03707-6

Author Correction: Mpox poses an ever-increasing epidemic and pandemic risk