health

Nature Medicine, Published online: 28 August 2025; doi:10.1038/s41591-025-03900-7

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Nature Medicine, Published online: 28 August 2025; doi:10.1038/s41591-025-03917-y

By matching antigenicity prediction with a forecast of circulating strains in the next season, a model is shown to outperform standard recommendations for vaccine design in terms of vaccine effectiveness and disease burden in multiple evaluations throughout different influenza seasons.

Nature Medicine, Published online: 27 August 2025; doi:10.1038/s41591-025-03923-0

Longitudinal analyses reveal misalignment between global research efforts and disease burden; the gap is expected to widen substantially over the next two decades by the withdrawal of US public funding for international research.

Nature Medicine, Published online: 27 August 2025; doi:10.1038/s41591-025-03899-x

In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and deletion of the PD-1 (PDCD1) gene were safe and associated with reduced disease activity.

Nature Medicine, Published online: 27 August 2025; doi:10.1038/s41591-025-03924-z

An AI model that integrates data from continuous glucose monitoring, microbiome analysis, physical activity levels and wearable sensors reveals hidden glycemic heterogeneity among individuals with identical HbA1c values. These nuances could improve the stratification of metabolic risk in decentralized clinical studies.

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Nature Medicine, Published online: 26 August 2025; doi:10.1038/s41591-025-03913-2

Analyzing data from the SURMOUNT-1 trial, the authors show that the weight loss effects of tirzepatide treatment are similar in carriers and noncarriers of MC4R pathogenic mutations.

Nature Medicine, Published online: 26 August 2025; doi:10.1038/d41591-025-00054-4

The recent defunding of USAID could lead to more than 14 million deaths, mostly in low- and middle-income countries, including 4.5 million child deaths — according to a study combining retrospective and forecasting analyses.

Nature Medicine, Published online: 26 August 2025; doi:10.1038/s41591-025-03975-2

Publisher Correction: Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG S1512 trial

Nature Medicine, Published online: 25 August 2025; doi:10.1038/s41591-025-03873-7

Two phase 2 trials, along with translational analysis of prospective cohorts and experimental analysis, indicate that immunosenescence as a mechanism of resistance to immunotherapy can be overcome with the senolytics dasatinib and quercetin in patients with head and neck squamous cell carcinoma.