health

Nature Medicine, Published online: 11 September 2025; doi:10.1038/s41591-025-03902-5

There are strong indications that MNP exposure negatively impacts human health, but a robust evidence base is lacking. This Review focuses on the current state of the science, offering a critical review of the data, analytical challenges and research priorities.

Nature Medicine, Published online: 11 September 2025; doi:10.1038/s41591-025-03936-9

In an irrevocably changed landscape, reform of the global health system needs to answer key questions on functions, what should be delivered in different contexts and at different levels, and how the system should operate.

Nature Medicine, Published online: 10 September 2025; doi:10.1038/s41591-025-03922-1

A retrospective, observational study shows that completion of a diabetes prevention program in England (the NHS Diabetes Prevention Programme) was associated with decreased incidence of type 2 diabetes and long-term conditions such as dementia and chronic obstructive pulmonary disease at 24 months.

Nature Medicine, Published online: 10 September 2025; doi:10.1038/s41591-025-03959-2

Critical evaluation of the ProfiLER-02 study design and outcomes

Nature Medicine, Published online: 10 September 2025; doi:10.1038/s41591-025-03960-9

Reply to: Critical evaluation of the ProfiLER-02 study design and outcomes

Nature Medicine, Published online: 09 September 2025; doi:10.1038/s41591-025-03926-x

This Review of the WHO’s International Clinical Trials Registry Platform presents a snapshot of the global cancer trial landscape and provides critical empirical evidence to inform policy, practice and investment.

Nature Medicine, Published online: 09 September 2025; doi:10.1038/s41591-025-03973-4

We assessed the utility of RNA sequencing in molecular diagnostics by analyzing a large pan-cancer cohort ranging in age from infants to seniors. This technique is highly sensitive for the identification of gene alterations that can guide diagnosis and targeted therapy, and enables additional biological and clinical interpretation of findings beyond standard DNA-sequencing protocols.

Sleep affects every aspect of our lives, from learning and memory to mood and behavior, so getting a good night’s rest is crucial. This is especially true for teens, who need no less than eight hours of sleep every night. However, being preoccupied with getting the right amount and right kind of sleep can lead to a relatively new sleep disorder called orthosomnia—the inability to fall or stay asleep caused by worrying that you’re somehow doing sleep wrong. Using an at-home sleep tracker like Apple Watch, the Oura Ring, and Fitbit can exacerbate the condition, too, according to expert Andrew Holmes of Sleep Efficiency. He says that these devices, while useful, have the potential to create a “negative feedback loop where it’s doing more harm than good.” If you use such a device, Holmes suggests checking its data weekly or even monthly instead of nightly. And instead of worrying about how much or how well you’re sleeping, take steps like going to bed and waking up at the same time every day, getting as much daylight as possible, and having a consistent exercise routine to ensure quality rest.

Nature Medicine, Published online: 08 September 2025; doi:10.1038/s41591-025-03932-z

In this phase 3 trial, a two-dose Ebola vaccine regimen in healthy pregnant women in Rwanda was found to be safe and immunogenic in women and offspring through passive transfer.

Nature Medicine, Published online: 08 September 2025; doi:10.1038/s41591-025-03859-5

Building the world’s first truly global medical foundation model