health

Nature Medicine, Published online: 02 October 2025; doi:10.1038/s41591-025-03765-w

Obesity and associated complications can be managed by obesity medications, prompting the revision of criteria for the diagnosis and staging of this disease.

Nature Medicine, Published online: 02 October 2025; doi:10.1038/s41591-025-04025-7

Author Correction: Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function

Nature Medicine, Published online: 01 October 2025; doi:10.1038/s41591-025-03946-7

In defense of Brazil’s resolution on transgender healthcare

Nature Medicine, Published online: 30 September 2025; doi:10.1038/s41591-025-03949-4

Analyses of the nationally representative Indian Council of Medical Research–India Diabetes survey reported that Indian diets are characterized by high intakes of low-quality carbohydrates associated with 14–30% higher cardiometabolic risk, which can be reduced by substituting carbohydrates with protein.

Nature Medicine, Published online: 30 September 2025; doi:10.1038/s41591-025-03964-5

In a combined analysis of two large patient cohorts, three peripheral consensus transcriptomic subtypes of sepsis are identified, which can be linked to an 18-gene classifier associated with different odds of mortality and may offer a way to tailor care for patients with sepsis.

Nature Medicine, Published online: 30 September 2025; doi:10.1038/s41591-025-03933-y

In a prospective study enrolling 1,222 patients from 22 emergency departments, a device using a machine-learning-based signature of blood mRNAs demonstrated clinically acceptable performance to diagnose bacterial and viral infections and to predict the all-cause need for critical care interventions within 7 days, with benchmark to established biomarkers and risk scores.

Nature Medicine, Published online: 30 September 2025; doi:10.1038/s41591-025-03994-z

When clinical trials are suddenly halted by US funding cuts, there are repercussions for investigators and patients, and they do not stop at borders.

Do you find yourself staying up later at night, and having a harder time getting out of bed early, as you age into your teen years? Part of the reason could be “sleep phase delay,” or the natural shift in your circadian rhythm that happens when you enter puberty. The sleep-inducing hormone melatonin is released into the brain around 8 p.m. in children age 10 and younger, but at the onset of puberty this release shifts to around 10:30–11 p.m. So there’s no need to worry if you’re becoming more of a night owl as you get older—just remember that, as a teenager, it’s recommended that you get between 8 and 10 hours of sleep every night.

Nature Medicine, Published online: 29 September 2025; doi:10.1038/s41591-025-03918-x

In the proof-of-concept phase 2 ROME trial, comprehensive genomic profiling followed by molecular tumor board evaluation and randomization of patients with metastatic solid cancer to receive personalized therapy or standard of care led to a significantly higher objective response rate and longer progression-free survival in patients who received personalized therapy.

Nature Medicine, Published online: 29 September 2025; doi:10.1038/s41591-025-03977-0

A phase 3 trial found that VER-01, a full-spectrum cannabis extract, reduces chronic low back pain, improves physical function and sleep and shows no signs of dependence or withdrawal.