wellness

The idea of getting an electric vehicle (EV) isn’t as enticing as it was just a few years ago. Not only did the $7,500 tax credit available for EV buyers expire in September 2025, but policies in the Trump administration’s tax and spending bill passed last summer removed fines on automakers who violated fuel-economy regulations. As a result, the focus on all-EV lineups from companies like Ford was largely abandoned. That doesn’t mean you’re resigned to buying an internal combustion engine (ICE) car, though—EV battery technology continues to get better, cheaper, and more durable, and car manufacturers are poised to offer a wider variety of hybrid models in the coming years.

Nature Medicine, Published online: 12 January 2026; doi:10.1038/s41591-025-04126-3

Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.

Nature Medicine, Published online: 09 January 2026; doi:10.1038/s41591-025-04134-3

A protein biomarker, the NOTCH3 extracellular domain, identifies individuals with idiopathic pulmonary hypertension, correlates with disease progression, improves mortality risk prediction and provides a readily implementable, noninvasive blood test for this disease.

Nature Medicine, Published online: 09 January 2026; doi:10.1038/s41591-025-04171-y

In a randomized, double-blind, placebo-controlled trial comparing autologous mRNA-engineered BCMA-targeting CAR T cell therapy versus placebo in patients with generalized myasthenia gravis, a significantly higher percentage of patients exhibited a reduction in disease activity in the treatment arm than in the placebo arm.

Nature Medicine, Published online: 09 January 2026; doi:10.1038/s41591-025-04170-z

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.

Nature Medicine, Published online: 09 January 2026; doi:10.1038/s41591-025-04135-2

We have identified serum levels of extracellular domain of NOTCH3 (NOTCH3-ECD) as a biomarker that can reliably distinguish idiopathic pulmonary arterial hypertension from other forms of pulmonary hypertension and healthy controls. Our findings show that serum NOTCH3-ECD levels are as accurate as current standard-of-care clinical tests in predicting disease progression and mortality risk.

Nutmeg (jaiphal) is a spice from the Myristica tree, mainly Myristica fragrans. The seeds are ground into powder to make the spice, while the red seed cover, called aril, is used for mace (javitri). Nutmeg and mace come from the same tree and taste similar. Nutmeg is often sold as whole seeds to be grated, …

Continue reading "Mace and nutmeg: Health benefits, risks, and how much you should really use"

Nature Medicine, Published online: 08 January 2026; doi:10.1038/s41591-025-04053-3

High-dimensional immune profiling of a living recipient of a pig-to-human xenotransplant provides insight into the immune landscape of xenotransplantation and directions for improved immunosuppression strategies.

Nature Medicine, Published online: 08 January 2026; doi:10.1038/s41591-025-04090-y

In a randomized phase 2 trial in patients with acute coronary syndrome and high levels of the inflammation biomarker C-reactive protein, treatment with low-dose interleukin-2 increased the numbers of regulatory T cells and reduced arterial inflammation, compared to placebo.

Nature Medicine, Published online: 08 January 2026; doi:10.1038/s41591-025-04122-7

China’s evidence-based re-evaluation of traditional Chinese medicine injections