wellness

Nature Medicine, Published online: 17 July 2025; doi:10.1038/s41591-025-03848-8

In a prospective study including 2,300 pediatric and adult patients with liquid and solid tumors, RNA sequencing provided actionable molecular information in 87% of cases, with applications in diagnostics and therapy matching.

Nature Medicine, Published online: 17 July 2025; doi:10.1038/s41591-025-03840-2

Physician-mediated genetic testing is direct to consumer in all but name

Nature Medicine, Published online: 16 July 2025; doi:10.1038/s41591-025-03813-5

This Review summarizes the current knowledge on mortality-defining toxicities of chimeric antigen receptor T cell therapies beyond cytokine-release syndrome and immune effector cell-associated neurotoxicity syndrome. The authors discuss underlying mechanisms and how these affect timing and management, and outline key unmet needs and future priorities.

Nature Medicine, Published online: 16 July 2025; doi:10.1038/s41591-025-03821-5

As patients move from WebMD to ChatGPT, Thomas Costello makes the case for cautious optimism.

Nature Medicine, Published online: 15 July 2025; doi:10.1038/s41591-025-03833-1

Large-scale plasma proteomics of 10,527 samples from the Global Neurodegeneration Proteomics Consortium identified shared and disease-specific pathways in Alzheimer’s disease, Parkinson’s disease and frontotemporal dementia.

Nature Medicine, Published online: 15 July 2025; doi:10.1038/s41591-025-03790-9

Deep phenotyping of an ancestrally diverse group of 13,000 individuals in the Human Phenotype Project highlights diversity and variations in lifestyle factors, clinical features and molecular signatures of health and disease.

Nature Medicine, Published online: 15 July 2025; doi:10.1038/s41591-025-03835-z

Over 11,000 plasma and cerebrospinal fluid proteomic samples reveal that the APOE ε4 genetic variant is associated with a systemic pro-inflammatory signature in a variety of neurodegenerative diseases.

Nature Medicine, Published online: 15 July 2025; doi:10.1038/s41591-025-03807-3

A new Global Neurodegeneration Proteomics Consortium provides a wealth of data to boost mechanistic understanding, biomarker research and drug development during aging and in neurodegenerative diseases — and dementia in particular.

Nature Medicine, Published online: 14 July 2025; doi:10.1038/s41591-025-03808-2

Analyses of the exposomes of populations across 40 countries found global disparities in healthy aging attributed to diverse biological, socioeconomic and political factors, with accelerated aging seen in populations from Egypt, South Africa, and Latin American and Caribbean regions.

Nature Medicine, Published online: 14 July 2025; doi:10.1038/s41591-025-03801-9

This Review discusses the scientific and technological breakthroughs reshaping transplant medicine, with a focus on the transformative role of artificial intelligence, xenotransplantation and tissue engineering as new sources of organs, and novel approaches to immunosuppression.