wellness

Nature Medicine, Published online: 11 November 2025; doi:10.1038/s41591-025-04047-1

Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.

Nature Medicine, Published online: 11 November 2025; doi:10.1038/s41591-025-04081-z

In older adults without cognitive impairment with higher levels of brain amyloid-β, physical inactivity was associated with accelerated accumulation of tau pathology and faster cognitive and functional decline. These findings suggest that even modest increases in daily physical activity might be linked to slower progression of preclinical Alzheimer’s disease.

Both houses of the U.S. Congress have introduced legislation to improve and enhance how sunscreens are produced, tested, and sold. The bills, each called the SAFE Sunscreen Standards Act, also aim to revamp the sunscreen regulation process, which some experts consider restrictive to the point that it inhibits development of new, better, and safer sunscreens. Such innovation, they say, could lead more people—especially those with darker skin—to use sunscreens more consistently. Over 210,000 new cases of skin cancer are projected to be diagnosed this year in the United States, while more than 80,000 cases are diagnosed in Canada every year.

Nature Medicine, Published online: 10 November 2025; doi:10.1038/s41591-025-04044-4

As presented at the American Heart Association Conference 2025, patients with chest pain and without obstructive coronary artery disease benefit from treatment informed by cardiovascular magnetic resonance.

Nature Medicine, Published online: 10 November 2025; doi:10.1038/s41591-025-04015-9

Research does not always ‘speak for itself’; high-fidelity uptake of science into policy requires active engagement between researchers and policymakers. This Perspective offers tangible recommendations to help bridge the research-to-policy gap.

Nature Medicine, Published online: 10 November 2025; doi:10.1038/s41591-025-04065-z

Author Correction: Global burden of chikungunya virus infections and the potential benefit of vaccination campaigns

Nature Medicine, Published online: 09 November 2025; doi:10.1038/s41591-025-04102-x

As presented at AHA Scientific Sessions 2025, in a trial emulation analysis including benchmarking to data from randomized clinical trials, treatment with semaglutide and tirzepatide showed similar levels of benefit on cardiovascular outcomes in individuals at elevated cardiovascular risk with obesity and diabetes.

Nature Medicine, Published online: 07 November 2025; doi:10.1038/s41591-025-04049-z

Elebsiran plus PEG-IFNα improved hepatitis B surface antigen (HBsAg) loss rates compared with PEG-IFNα alone in patients with chronic hepatitis B virus infection. Furthermore, prior response to the BRII-179 vaccine was associated with higher HBsAg clearance, suggesting its potential as a predictive tool for identifying patients more likely to benefit from therapies.

Nature Medicine, Published online: 06 November 2025; doi:10.1038/s41591-025-04057-z

In a meta-analysis of 48 randomized trials of chronic kidney disease progression, reduction in the 6-month urinary albumin:creatinine ratio was associated with lower hazard ratios of established kidney disease endpoints, supporting the use of albuminuria change as a surrogate endpoint in clinical trials for chronic kidney disease.

Methodology refinements grant hospitals more flexibility and provide more timely information to expectant parents