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Nature Medicine, Published online: 30 January 2026; doi:10.1038/d41591-026-00005-7

Using a new approach to control for genetic and environmental confounders, a review and meta-analysis finds no link between paracetamol use during pregnancy and neurodevelopmental outcomes in children.

Nature Medicine, Published online: 30 January 2026; doi:10.1038/d41591-026-00004-8

In patients with T cell acute lymphoblastic leukemia, base-edited CAR T cells — capable of destroying leukemic T cells while they themselves are protected — induced remission and allowed progression to stem-cell transplantation.

Nature Medicine, Published online: 30 January 2026; doi:10.1038/d41591-026-00006-6

A study shows that social interactions in the nursery have a huge impact on babies’ microbiome development and may facilitate rapid strain recovery after antibiotic treatment.

U.S. News will debut ratings of almost 8,000 home health agencies on February 24

Nature Medicine, Published online: 28 January 2026; doi:10.1038/s41591-026-04233-9

Author Correction: Intrathecal onasemnogene abeparvovec for treatment-experienced patients with spinal muscular atrophy: a phase 3b, open-label trial

Nature Medicine, Published online: 28 January 2026; doi:10.1038/s41591-026-04236-6

Publisher Correction: argeting of HIF2-driven cachexia in kidney cancer

Nature Medicine, Published online: 28 January 2026; doi:10.1038/s41591-025-04189-2

In a double-blind, placebo-controlled phase 2 trial in patients with metastatic renal cell carcinoma treated with anti-PD-1 plus a VEGFR tyrosine kinase inhibitor, donor fecal microbial transplantation (FMT) from complete responders to immunotherapy did not significantly improve the primary endpoint of 12-month progression-free survival (PFS) but did significantly improve median PFS versus placebo FMT.

Nature Medicine, Published online: 28 January 2026; doi:10.1038/s41591-025-04186-5

In a phase 2 trial evaluating healthy donor fecal microbial transplantation plus either anti-PD-1 in patients with non-small cell lung cancer or anti-PD-1 and anti-CTLA-4 in patients with melanoma, encouraging efficacy was seen in both cohorts, with responses linked to significantly greater loss of baseline bacterial species.

Nature Medicine, Published online: 27 January 2026; doi:10.1038/s41591-025-04177-6

Transcriptomic and clinical data analyses from multiple cohorts of patients with cancer receiving immunotherapy find that PD-1 blockade potentiates tumor-specific IgG1 plasma cell responses that complement cellular immunity and contribute to clinical benefit.